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Ding, X., Kakanj, P., Leptin, M., & Eming, S

IGF-1 LR3 (insulin-like growth factor-1 long arginine 3) is a synthetically modified derivative of insulin-like growth factor-1, which is produced in the liver in response to growth hormone endocrine stimulus

It is recognized for potential therapeutic effects on gastrointestinal health and tissue repair , supporting the healing of muscles , tendons , and the gut lining

also found that mutations in SPOCK2 and CHST3 potentially contribute to disc generation and general back pain in a study of 509,000 European individuals ( SOX5 , CCDC26/GSDMC , and DCC loci are associated with back pain based on another study of Caucasian individuals in Norway (Lie et al., 2022)