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J Neurosurg Spine, 114:21, 2011

The increased glomerular permeability and subsequent interactions between tubular injury, tubulointerstitial inflammation, and the progression of lupus nephritis (LN) towards renal dysfunction result in additional tissue damage in lupus

Furthermore, the cell membrane-coated ZIF-8@MnOx nano-platform mPDZM simultaneously loaded with doxorubicin and piperlongumine can effectively promote CD8 + T cell and NK cells infiltration by regulating SASP release, inducing ICD and activating the STING signaling pathway, while reducing Tregs and M2-like macrophages and can further enhance anti-tumor immunity and produce a strong abscopal effect on distant tumors when combinated with anti-PD-L1 therapy (235)