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Once absorbed, heme can be transported from vesicles to the cytoplasm via heme-responsive gene 1 (HRG-1) and subsequently metabolized by heme oxygenase 1 (HO-1) in the endoplasmic reticulum, releasing ferrous ions that contribute to the cytoplasmic iron pool

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Diabetes Care 43(5):940-7 2020 PMC7171946 Mather KJ, Bebu I, Baker C, Cohen RM, Crandall JP, DeSouza C, Green JB, Kirkman MS, Krause-Steinrauf H, Larkin M, Pettus J, Seaquist ER, Soliman EZ, Schroeder EB, Wexler DJ, Pop-Busui R, GRADE Research Group