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The critical role of eicosanoids in the mediation of a plethora of biological processes has been thoroughly studied and reviewed in the literature 3134 and will not be further discussed

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Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor

Acknowledgments Authors express special thanks to Ken Rory and many other colleagues of the Academiacs International network ( accessed on 14 May 2021) for helpful discussions and inspiration