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Aged human skin accumulates mast cells with altered functionality that localize to macrophages and vasoactive intestinal peptide-positive nerve fibres
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6.6 Anchors to the mechanism sections: ferroptosis and the gutbrain axis 6.6.1 FerroptosisNrf2 intersection Recent PD-focused syntheses place GPX4 activity, iron handling, and lipid peroxidation at the core of ferroptotic vulnerability
doi: 10.1111/imj.13104 [PubMed] 28489461 Levine M, Stellpflug S, Pizon AF, Traub S, Vohra R, Wiegand T, Traub N, Tashman D, Desai S, Chang J, Nathwani D, Thomas S

Nonetheless, larger-scale and long-term clinical trials are still needed to validate the efficacy and safety of AST in cardiovascular disease treatment

Results vary by individual
