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Compounds that were selective toward the closely related APN and that exhibited sub-M affinity were identified

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In addition, changes in the levels of proteins, such as A42, tau, and neuron-specific enolase in the serum or cerebrospinal fluid, also provide clues to the mechanism of disease-induced neurodegeneration (70, 71)

Sermorelin was approved for treating growth hormone deficiency in children, though the manufacturer pulled it from the market in 2008 for commercialnot safetyreasons
