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doi: 10.3389/fnagi.2022.986443 32 LiY.WuM.KongM.SuiS.WangQ.HeY.et al

However, one school of thought maintains that inclusion of placebo subjects in FIH trials, which are underpowered, is not justified or useful.33 Most AEs observed in FIH studies are just reported as probably related with minimal interpretation of causality and more serious AEs are typically followed with greater diligence and concern

Instead, it is almost always positioned as a high-performance treatment serum designed for advanced skincare routines

urinary retention (BOTOX 17%, placebo 3%)

Optional research biomarkers: senescence markers (p16^INK4a, SA--gal), SASP cytokine profile (IL-6, IL-1, MMPs) if lab resources permit