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doi: 10.3389/fphys.2019.01607 71 NiczeMDecABorowkaMKrzyzakDBoldysABuldakLet al

H., Wu C

Biochim Biophys Acta 1830, 31393142 (2013)

In vitro studies have found that in IDH1 mutant glioma stem cells (TS603), the expression of genes related to ROS clearance is overall upregulated, and the gene that regulates glutathione synthesis, SLC7A11, is most upregulated

SNCA dosage modulations, precise corrections and loss-of-function models in hPS cell-derived DA neurons define SNCA gene-dosage-dependent aggregation and toxicity and demonstrate the rescue of mitochondrial and electrophysiological phenotypes upon correction 35,36,42
