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This is because the 4-OH metabolites can create reactive products that damage DNA

Your skin is a canvas that reflects your inner health, environment, and care routine

However, since small intestinal permeability was significantly higher in patients with alcoholic liver diseases than in patients with chronic alcohol abuse in the absence of liver disease, the direct barrier toxicity of alcohol does not fully account for the permeability defect (155)
A similar result was found in mice challenged with B16-F10 cells (Supplementary Fig

doi: 10.1161/circresaha.116.306819
