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In canonical Wnt/-catenin signaling, the secreted Wnt proteins bind with the Frizzled receptor and a co-receptor of the low-density lipoprotein-related protein (LRP), thereby inactivating glycogen synthase kinase-3 (GSK-3), which is an enzyme responsible for phosphorylation and ubiquitination-mediated degradation of -catenin

NAD+ serves as a substrate for sirtuins and PARP enzymes, which regulate DNA repair and mitochondrial function

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