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In the presence of such heterogeneity, TrkB modified therapeutic agents, as well as the use of epigenetic modulator interventions may be part of the solution to restore neuroplasticity and slow disease progress [298]

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Unfortunately, there is not a definite answer to how bioavailable oral supplements are, as everything from the type of vitamin to the health of your gastrointestinal tract affects your bodys ability to process and absorb nutrients

doi: 10.1038/scientificamerican0809-54