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Mooney, F
The mechanism is well-established: GHK-Cu modulates over 4,000 genes, upregulating genes responsible for collagen and elastin synthesis, angiogenesis, and antioxidant production while downregulating pro-inflammatory and fibrotic pathways
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O'Brien ML, Vulevic B, Freer S, Boyd J, Shen H and Tew KD

Therefore, IR, HA and obesity are the main factors contributing to the increased risk of pregnancy-induced hypertension in patients with PCOS