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doi: 10.1038/nrmicro.2017.157 28 HasanNYangH

PKA and transcription-factor signaling Afterward, cAMP activates protein kinase A (PKA), which supports CREB signaling and increases expression and activity of microphthalmia-associated transcription factor (MITF)

The impaired renal TMAO clearance may lead to elevated circulating TMAO concentration and reduced glomerular filtration rate, which could aggravate burden of kidney (Toyohara et al., 2010

No deaths have been reported when poison centre reports were analysed for ATX overdoses, and doses up to 2840 mg have been reported to cause seizures and GI problems (Kashani and Ruha, 2007[56]

LPS can induce foam cell formation and cholesteryl ester accumulation from native low density lipoprotein, indicating LPS is proatherogenic (Lakio et al., 2006