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Structurally, Dihexa is derived from angiotensin IV a naturally occurring peptide involved in brain function but has been chemically modified to dramatically enhance its potency and its ability to penetrate the blood-brain barrier

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[DOI] [PubMed] [Google Scholar] 75.Jimenez A.G., Downs C.J

The intranasal therapeutic strategy has been increasingly explored as it facilitates the BBB bypass, granting a direct transportation of therapeutics into the brain via the nasal cavity