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Notably, Piezo1 overexpression abolished the regulatory effects of LIG (Na) on mitophagy, whereas Piezo1 knockdown (sh-Piezo1) did not attenuate its efficacy

Rossato et al., 2016

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Depolarization of endothelial cell membranes induces ROS production and subsequent inflammation ( 3.2.2 Application of PCLS to measure calcium overload Intracellular calcium overload is one of the main pathological mechanism of lung IRI ( 2+ levels in lung slices, a previous study showed that Ca 2+ oscillations are essential for maintaining the contractile state of the airway smooth muscle cells and, thus, the airway contraction ( 2+ in PCLS ( 2+ signaling has been possible by combining the PCLS with real-time confocal or two-photon microscopy ( ex vivo PCLS to decipher the relevance of calcium and ion-mediated signaling in post-LTx IRI