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its inhibition promotes aNSC differentiation, and its levels naturally decrease as differentiation proceeds

This signaling pathway is essential for the hypertrophic effects of IGF-1.23 Notably, IGF-1 has also been shown to promote intracellular lipid accumulation in mesangial cells, a phenotype similar to foam cells, which leads to reduced contractility in response to angiotensin-II.24,25 Furthermore, kidney samples from patients with advanced CKD and mouse models with renal fibrosis have defective fatty acid oxidation and higher lipid accumulation than controls without fibrosis

The mechanisms underlying Chinese medicines to treat inflammation in diabetic kidney disease

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A coffee enema rather than an oral dose was utilized in this study because 1 L of coffee extract is difficult to ingest in addition to the customary 2 L of PEG, and the coffee solution itself could impede VCE