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Study finding The researchers found that the booster dose did not cause a higher rate of local or systemic adverse reactions within seven days of the injection as compared to the placebo

These findings are consistent with earlier reports describing an inverted U-shaped doseresponse relationship, underscoring the importance of further investigation into the pharmacodynamic profile of GlyT1 inhibitors

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The long-chain fatty acids that should be burned for energy instead accumulate outside the mitochondria, leading to a state of lipotoxicity and cellular stress

A., Circulation 2015, 131, 1435