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Findings of the Included Quasi-Experimental Study
Stier, H., Vos, E., & Kenley, D
Renal impairment affects not only the renal excretion of a drug but may also alter metabolism and active transport in the kidney, liver or gut and affect absorption, tissue distribution and plasma protein binding [13]

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An excellent overview by Gwen Dewar explains the role of cortisol during pregnancy
