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It is well established that 1A -ARs experience less phosphorylation, desensitization, and internalization on agonist stimulation than the 1B - and 1A -AR subtypes (Akinaga et al., 2013)

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pylori VacA reduces GSH levels leading to ROS accumulation and activation of protein kinase B (AKT) induced autophagy and CagA degradation

Glutathiona synthesis[J]