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This leads to the formation of regenerative hepatic nodules encased in dense fibrous tissue, containing significantly higher levels of extracellular matrix proteins, particularly collagen types I, III, and IV, which hinder portal blood flow and elevate portal pressure, ultimately culminating in clinically significant portal hypertension in later disease stages (1)

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In this process, medium-chain fatty acids are directly oxidized in the mitochondria to generate acetyl-CoA, which subsequently enters the citric acid cycle (TCA cycle) for ATP generation

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'82 Stephen M