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[145] [147] [166] In particular, aerobic exercise decreases psychostimulant self-administration, reduces the reinstatement (i.e., relapse) of drug-seeking, and induces increased dopamine receptor D 2 (DRD2) density in the striatum

The development of atherosclerotic plaques has been associated with activation of hypothalamic nuclei involved in sympathetic regulation, supporting a role for central neural mechanisms in modulating plaque progression and vascular inflammation (53)