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The review concludes with an outlook on future directions, aiming to advance the understanding of the cancer metabolic regulatory network and to inform the development of novel metabolism-based therapies

The choice of treatment regimen should be based on the latest evidence and adjusted dynamically as the disease progresses

The high response rates to placebo after optimizing standard treatment and a suboptimal dosing regimen of epratuzumab may have resulted in trial failure

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Khiavi NMN, et al
