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The A plaques arise extracellularly following aberrant cleavage of amyloid precursor protein (APP) by beta- and gamma-secretases, whereas tau, a microtubule-associated protein, becomes abnormally hyperphosphorylated, detaches from microtubules, and aggregates into intracellular tangles [84]
however, the precise initiating events remain unclear
The amount of water you add determines the concentration, which determines how much liquid you draw for each dose
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Each of these inhibited pathways results in the diversion of acetyl-CoA into de novo fatty acid synthesis
