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Low levels of B12 can lead to hyperpigmentation, vitiligo, pale or jaundiced skin, and premature signs of aging like fine lines and wrinkles

N Engl J Med 343 : 923930 Mauras N et al
Activation of amylin receptors triggers signalling pathways that promote satiety and reduce food intake, partly by enhancing feelings of fullness and reducing hedonic eating drive

Altelaar, A