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The intrinsic factor-mediated pathway operates regardless of food presence, and the passive diffusion mechanism (responsible for absorbing about 1% of high doses) similarly functions independently of meals

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[1] Women using oral contraceptives should use a backup method for 4 weeks after tirzepatide initiation and each dose increase due to potential reduced contraceptive effectiveness

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Peptide compounds interact with your endocrine and immune systems and require licensed medical oversight for safe, effective results