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Besides, unlike other non-biodegradable inorganic nanomaterials, MnO 2 can be broken down into the harmless water-soluble Mn 2+ that can be rapidly eliminated by renal metabolism without long-term in vivo toxicity (Chen et al., 2016

Its something your body naturally produces

Diet sets the stage

Reduced glutathione is the bioactive form that the body can use directly without conversion steps

Therefore, LPs should be modified with ligands for appropriate BBB receptors to enhance their penetration into the brain [20, 21]
