glutathione pathway breast cancer A scheme of the mechanism of CHAC1 degradation of enhancing Amino acid metabolism in breast
Description
Nat Commun (2022) 13:187

Our results revealed that 6-thio-dG exhibits non-competitive inhibition concerning the GSH substrate while showing mixed-type inhibition with CDNB

siRNA sequences to knock down Hsf1 are: Antisense1: rCrUrUrGrArUrGrUrUrCrUrCrArArGrGrArGrCrUrGrCrUrCrCrUrG Sense1: rGrGrArGrCrArGrCrUrCrCrUrUrGrArGrArArCrArUrCrAAG Antisense2: rArArGrUrGrGrUrCrArCrUrGrArGrCrUrCrArUrUrCrUrUrGrUrCrC Sense2: rArCrArArGrArArUrGrArGrCrUrCrArGrUrGrArCrCrArCTT Negative control siRNA - IDT catalog no
That works perfectly for insulin, which is standardized at known concentrations

doi: 10.1038/s41586-019-1170-y 116 Ruiz-OjedaFJGomez-LlorenteCAguileraCMGilARuperezAI
