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The primary storage unit for vitamins such as A, D, E, K, and B12 is the liver

191 Once-daily administration of roflumilast significantly improves forced expiratory volume in 1 s and decreases exacerbations, particularly in patients with severe disease, 192,193 but has side effects such as nausea, vomiting and headache

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In FOURIER, evolocumab reduced LDL-C and significantly lowered cardiovascular event risk in patients with established ASCVD (Sabatine et al., 2017)