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R., Poulsen, M., Beemelmanns, C

The ligand of the protein encoded by GPR39 is encoded by GPNMB [430], and GPNMB was a DEG in three studies: E26 [212], E29 [157], and E49 [166]

doi: 10.1089/ars.2012.5149 35 WangPGongQHuJLiXZhangX

Zinc transporters ZnT3 and ZnT6 are downregulated in the spinal cords of patients with sporadic amyotrophic lateral sclerosis

Complementary clinical and meta-analytic data consistently demonstrate systemic redox imbalance, including lower glutathione reserves, altered GSH/GSSG ratios, increased lipid peroxidation, and dysregulated NRF2 signaling, linking oxidative status to immune activation and synaptic dysfunction (James et al., 2004