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Neuropathological investigations in the substantia nigra pars compacta of Parkinsons disease patients demonstrate that deficient PGC-1 expression compromises mitochondrial biogenesis and disrupts the coordinated transcriptional activation of antioxidant stress-responsive gene networks, thereby precipitating dopaminergic neuronal degeneration (Piccinin et al., 2021)

10.1097/00003086-199704000-00029 60 KeremiB.LohinaiZ.KomoraP.DuhajS.BorsiK.Jobbagy-OvariG.et al (2009)

A downside of NER + L-based coding is that it requires contextual understanding, i.e., the negation, temporality, and experiencer of the extracted concept or code 35,65 , which are not needed using the multi-label classification approach

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