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A revised reference list of genotoxic and non-genotoxic chemicals recommended for assessing the performance of new or improved in vitro genotoxicity test methods has been developed to fit the following different sets of characteristics (Kirkland et al., 2016): Group 1: Chemicals that should be detected as positive in in vitro mammalian cell genotoxicity tests

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At 24 h, the upregulation of HMOX1 and GADD45B remained significant in both cell types, but DNAJB1 regulation declined and was no longer significant in HepG2 ATP7B-KO cells

Reduced glutathione with sulfurs lone pair electrons displayed by dots