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Upon activation, CX3CR1-mediated chemotaxis induces a shift to an amoeboid shape, accompanied by upregulation of TREM2-dependent phagocytic receptors and P2X7R activation, triggering dynamic secretion of pro-inflammatory cytokines (e.g., IL-1, TNF-) or anti-inflammatory factors (e.g., IL-10, TGF-)
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Mechanistically, it activates the PI3K/AKT signaling pathway to promote cell proliferation, invasion, and migration [55]
