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Abbreviations AS: Alternative splicing CDNB: 1-Chloro-2,4-dinitrobenzene ES: Exon skipping GS-DNB: S-(2, 4-dinitrophenyl)-glutathione GSH: Glutathione GST: Glutathione S-transferase IR: Intron retention KEGG: Kyoto Encyclopedia of Genes and Genomes MAFFT: Multiple alignments using fast Fourier transform MeJA: Methyl jasmonate ML: Maximum likelihood MW: Molecular weight NCBI: National Center for Biotechnology Information ORF: Open reading frame pI: Isoelectric point ROS: Reactive oxygen species TSS: Transcription start sites TTS: Transcription terminal sites UTRs: Untranslated regions References Basantani M, Srivastava A

Under normal conditions, Keap1 complex-mediated ubiquitination degrades Nrf2, and when confronted with oxidative stress, Keap1 complex activity is inhibited and the Nrf2/ARE pathway is activated

Similarly, vanadium inhibited SOD activity in chicken liver and kidney [148]

Proper mixing supports consistent treatment results for patients

Measurement of Lipid Peroxidation Lipid peroxidation level in the brain cell homogenate was quantified using the thiobarbituric acid reactive substances (TBARS) as previously described (Buege and Aust, Measurement of Protein Carbonyl Content Protein carbonyls were used as a measure of protein oxidation, in brain cell homogenates using DNPH as previously described (Levine et al., Measurement of Superoxide Dismutase (SOD) and Glutathione Peroxidase (GPx) of the Antioxidant Enzymes Activity Superoxide dismutase (SOD) and GPx activities were quantified using commercially available kits (Cayman chemicals) according to the manufacturers guidelines