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Cumulative evidence points at alterations in neurotransmitter systems in fibromyalgia, which influence pain perception, fatigue, sleep disturbances, and depressive as well as anxiety-related symptoms (Figure 1)

[PubMed: 34113959] 36

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The function of gastrointestinal epithelial barrier is to protect against the entry of foreign antigens and microorganisms, while allowing the absorption of essential nutrients, water and electrolytes [2, 7]
