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Only 12% of an oral crystalline dose of non-protein bound vitamin B12 as occurs in fortified foods and supplements is absorbed by simple passive diffusion throughout the length of the gastrointestinal tract (Doets et al., 2013)

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Research shows that people who used semaglutide had lower vitamin B12 levels (they also had bariatric surgery before using semaglutide), and another study concluded that people with obesity had lower B12 levels

B12 deficiency can lead to negative side effects

2 mg/week: 5 weeks per vial 4 mg/week: 2.5 weeks per vial 5 mg/week: 2 weeks per vial 8 mg/week: 1.25 weeks per vial 10 mg/week: 1 week per vial This creates a planning challenge