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Simultaneous oxygen consumption rate, reactive oxygen species production, and membrane potential Mitochondrial respiration, ROS production, and membrane potential in response to an ADP titration were assayed in isolated skeletal muscle mitochondria using an Oxygraph 2 K dual respirometer/fluorometer (Oroboros Instruments, Innsbruck, Austria) (Fig

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Protons then flow through ATP synthase along the chemical gradient to combine with adenosine diphosphate (ADP) and inorganic phosphate (Pi), creating ATP (Figure 1)

Carbamidomethylation of cysteines was defined as a fixed modification, while protein N-terminal acetylation and methionine oxidation were defined as variable modifications for database searching

Common variants that are associated with blood pressure in genome-wide association studies implicate the kidney, adrenal gland and vasculature in the development of hypertension