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In conclusion, while the fundamental aspects of neuronal energy metabolism are well-documented, ongoing and future research will likely focus on the complex regulatory networks that enable neurons to maintain energy homeostasis, particularly under stress or disease conditions (Antal et al., 2025)

Fluorine, a highly electronegative atom, is important in medicinal chemistry, where a single fluorine incorporation in small molecules can increase pharmacokinetic and physicochemical properties, improve metabolic stability and enhance membrane permeation 41

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