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doi: 10.1152/physiol.00012.2016 [DOI] [PMC free article] [PubMed] [Google Scholar] 404

The massive release of glutamate during cerebral ischemia reverses the physiological transport gradient of System Xc (Bridges et al
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This stability is attributed to its unique amino acid composition, which includes multiple proline residues that create conformational constraints resistant to protease activity

This is one reason gentle handling is emphasized

Using the redox proteomics technique, a cysteine cluster in the proximity of the regulatory phosphorylation sites within the C1-M-C2 domain was identified, showing enhanced GS-ylation in patients [41]
