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The enzymatic activity of EL is dependent on several factors

Teichman SL et al

Oral Oncol 51(6):557564 Shibata A, Nakagawa K, Yamanoi H, Tsuduki T, Sookwong P, Higuchi O, Kimura F, Miyazawa T (2010) Sulforaphane suppresses ultraviolet B-induced inflammation in HaCaT keratinocytes and HR-1 hairless mice

252 Regardless, the conservation and interdigitated nature of the residues that form coordination bonds to one or the other regulatory site (site 1 in these structures corresponds to site 3 in other Furs with the S 4 site) allows for a significant degree of plasticity in the coordination chemistry