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Our research indicates that IGF1R could be a potential biomarker for early prediction of drug response and clinical evolution of NSCLC patients

Statements Author contributions HA and DZ: conceptualization

A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimers disease

From the earliest prokaryotic lifeforms, the ability to sense and anticipate environmental cycles conferred evolutionary advantages, leading to the emergence of endogenous circadian clocks that regulate nearly every aspect of physiology

Melatonin has also been shown to be effective at the cardiovascular level in lowering blood pressure in humans, type 1 diabetic adolescents (Cavallo et al., Another study showed that melatonin is a valuable therapeutic agent against ischemic stroke related to aging, demonstrating that aged Wistar rats treated with melatonin from 24 h prior to until 7 days after an induced ischemic stroke had a significant reduction in the concentrations of glial fibrillary acidic protein, TNF-, IL-1, Bcl-2-associated death promoter, and Bcl-2-associated X protein in both the hippocampus and brain cortex, while the hippocampal concentrations of sirtuin 1 and Bcl-2 were increased