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Patients frequently experience: Fatigue and generalised weakness that persists despite adequate rest Breathlessness on exertion due to anaemia Palpitations and reduced exercise tolerance Pallor of the skin and mucous membranes These symptoms result from megaloblastic anaemia, where impaired DNA synthesis leads to the production of abnormally large, dysfunctional red blood cells with reduced oxygen-carrying capacity

Enjoy reading: To view or add a comment, sign in FDA research shows that the 773 generic drug applications approved in 2023 generated an estimated $18.6 billion in savings in the twelve months following approval

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doi: 10.1038/nrurol.2016.23 26 ZhaoWSunJYaoLYHangDLiYQChenCPet al