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As is known to all, the neurotransmitter serotonin, whose functions are conserved in many species, is a major driver of body fat loss and energy expenditure

is manifested by decreased insulin-stimulated glucose transport and metabolism in adipocytes and skeletal muscle and by impaired suppression of hepatic glucose output

(2022) 14(3):e22849

Jul 2016;12(6):1213-9

In another trial, a combination of extracts from irvingia and Cissus quadrangularis , a West African vine, produced significantly larger reductions in body weight and fat, total cholesterol, LDL cholesterol, and fasting blood glucose compared with the Cissus extract alone (Oben, Ngondi, Momo 2008)