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LPS activates NF-B signaling through the TLR4/CD14-MyD88-dependent pathway, inducing excessive production of pro-inflammatory cytokines such as TNF- and IL-6, triggering systemic low-grade chronic inflammation (93)

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Cytochromes P450, UGTs, sulfotransferases, and catechol- O -methyltransferases are just a few of the major enzymatic families that metabolize estrone, for example (3741)

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10.1080/15548627.2016.1187366 44 HuangF.XuL.NiuW.ZhangY.LiS.LiX.et al (2022a)