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In longitudinal models, which included interactions with time, there were significant interactions between VDD and pack-years of smoking in association with the rate of FEV 1 decline ( P = 0.02) and a trend toward significance with FVC decline ( P = 0.08) and with smoking status in relation to FEV 1 ( P = 0.052) and to FEV 1 /FVC decline ( P = 0.02), where smokers with VDD had greater lung function decline compared with those without VDD

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