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Description
The two D-amino acids at positions 3 and 4 (D-2Nal and D-Phe) provide both metabolic stability and receptor selectivity

Despite significant advances in understanding PD pathogenesis, effective disease-modifying therapies remain elusive, underscoring the need for further research into the molecular mechanisms underlying the disease

Irwin MR, Olmstead R, Motivala SJ (2008)

Agyare EK, Jaruszewski KM, Curran GL, Rosenberg JT, Grant SC, Lowe VJ, et al

In September 2024, the FDA removed them from Category 2 but hasn't added them to Category 1
