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The term cellulite, in aesthetic medicine, refers to the alteration of the skin surface that causes the orange peel appearance, but outside the field of aesthetics, cellulite is an inflammation of the cells caused by bacteria and treated with antibiotics (infectious cellulitis), therefore, they must be distinguished.Curiously, calling these irregularities that we see in the skin cellulite began to be used in the 1920s, but we also know it as the aforementioned orange peel skin or other more technical terms such as nodular liposclerosis or lipodystrophy, among others.Luckily, women today are more informed and opt for naturalness and health, escaping from ideal bodies and opting for reality, thus taking care of their self-esteem and mental well-being

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Hep-G2 cells with MIA3 overexpression were subjected to RNA-seq, and the downstream target gene CHAC1 (glutathione-specific -glutamyl cyclotransferase 1) was selected according to the results of the volcano map of gene enrichment