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Secondly, if extreme doses are taken, its often for a minimal amount of time before the unwanted effects turn out to be unbearable

(iii) increased production of cytotoxic ROS 155,156
For example, too much vitamin B6 may cause severe skin lesions, along with other symptoms like numbness, digestive issues, and poor muscle control, according to Mayo Clinic

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Stable gastric pentadecapeptide BPC 157 as a therapy for the disturbances of the venous system
