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This is often due to circumstances other than the cartilage defect or procedure itself

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10.1016/j.cgh.2009.04.024 170

Ethics approval and consent to participate This article does not contain any studies with human participants or animals performed by any of the authors

366,453,454 The relationship between these structural and functional brain changes and metabolic factors remains poorly understood, with potential mechanisms including vascular injury, oxidative stress, osmotic imbalances, and glial and neuronal damage