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The reason is relatively straightforward
10.1039/c5mb00101c 36 FeigD
Early Tensile Loading in Nonsurgically Treated Achilles Tendon Ruptures Leads to a larger Tendon Callus and a Lower Elastic Modulus: a Randomized Controlled Trial
Ursodeoxycholic acid 'mechanisms of action and clinical use in hepatobiliary disorders'
Blunted or impeded therapeutic response to vitamin B12 may be due to such conditions as infection, uremia, drugs having bone marrow suppressant properties such as chloramphenicol, and concurrent iron or folic acid deficiency
