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NNMT consumes S-adenosylmethionine (SAM) and methylates nicotinamide, depleting cellular methyl pools and downstream NAD+ precursors

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Conclusion All IM, oral, and SL routes of administration of vitamin B12 can effectively increase the level of vitamin B12 without significant differences between them, as thought previously

By influencing NAD-related pathways, it provides researchers with a focused tool for investigating cellular energy balance, metabolic regulation, and molecular signaling in controlled laboratory environments